What is the Difference Between Restylane and Radiesse?

Restylane, Perlane and Juvederm are made of hyaluronic acid (HA), a component of our natural connective tissue underneath the skin. Radiesse is made of calcium hydroxyapatite micronized granules which can be thought of as a synthetic grounded up bone structure. Longevity for HA fillers is 4-9 months for Restylane or Juvederm, 6-10 months for perlane. Longevity for Radiesse is typically 9-18 months. Evolence is a purified porcine collagen which has virtually zero allergenicity in clinical... more

Restylane is made out of hyaluronic acid and has much less risk (it is reversible if you don't like it). On the other hand, Radiesse is calcium based and can stay for years (especially if you don't like it!). We don't use Radiesse for that reason as well as the fact that it hurts quite a bit more than Restylane. Good luck!

There are several differences. Restylane and Juvederm are hyaluronic acids which are found naturally in our bodies in the dermis underneath the epidermis. It is a sugar-water molecule and is dissolved by our metabolism. These products are injected in many different areas of the face including the lips. Radiesse is calcium hydroxylapatite which is a naturally found precursor to bone formation in our bodies. It is not meant to be injected into the lips but is used for volume restoration of... more

Hi Haley, The main difference between different fillers is how they respond with your body. Radiesse is a substance similar to ground up bone. Juvederm and Restylane are smooth gels that are a normal skin substance. We very much prefer Juvederm and Restylane to Radiesse because, while both can give you very nice results, Juvederm and Restylane can be quickly and easily dissolved. That way if there is any part of your treatment that is not perfect we can remove that part of the filler... more

Restylane is a soft colorless gel which goes away in about six months. Radiesse is a soft white tooth paste like material which gets absorbed in about one year. Neither needs a skin test. Restylane can be used in lips while Radiesse cannot be used in that area. Regards