My doctor took collagen from my TT revision and inserted it into my lips for volume, is this also called alloderm? (photos)
Doctor Answers 4
Use of your own dermis is not the same as Alloderm from a cadaver
Use of your own de-epithelialized (epidermis removed) dermis is similar to Alloderm, however your own tissues contain living cellular elements that you will tolerate without immune reaction when they are prepared and grafted elsewhere in your body. You would not tolerate the unprocessed dermis from another individual, as a transplant, as you would respond with a graft rejection reaction, unless treated with immunosuppressive drugs, like after a kidney transplant. Alloderm and the other human acellular dermal grafts (Neoform and Flex-HD) are harvested from cadavers and then processed to remove all living cellular elements that would cause a transplant immune rejection reaction, and they thus only contain a scaffold of human collagen protein, which is the same in all humans, and thus does not cause an immune rejection response. Such grafts are eventually incorporated into the body and then replaced with an individual's on collagen, acting as a scaffold on which cellular deposition and growth can occur. By the way, acellular dermal grafts to not work very well in the lips as they are unable to easily be incorporated by blood vessel ingrowth. I have not done one of these in a long time, because of the swelling that occurs, and the worry that ensues, but once the swelling subsides, the results tend to look good, and the tissues are usually incorporated into your tissues. Swelling may last 2 weeks or more. Presently I prefer injections of JuveDerm, as it is readily available, well-tolerated, and has low risk in experienced hands. A link is found below. Ask your surgeon for more information about what to expect.
Tom DeWire, MD, FACS