What Causes Fainting from a Wrinkle Filler Injection?

It is extremely uncommon for one to lose consciousness during a filler treatment to areas such as the nasolabial folds. There are two circumstances in which I have witnessed this, however.

The first may be a fear of needles. Some patients have a true needle phobia and will briefly "pass out" when the needle is nearby. This can sometimes be amplified by hypoglycemia or dehydration.
The other scenario is when epinephrine is included in the block used to numb the area. Epinephrine will sometimes cause a rapid heart rate that in turn may cause a person to pass out briefly.

I would suggest asking your doctor whether or not epinephrine is in the local anesthetic they choose. We are certainly able to use other types that do not have it.
If you know that you get light headed around needles or blood, be sure to let your doctor know so that she can use the appropropriate steps to avoid this problem.
Some patients with severe phobias benefit from hypnosis therapy.

People are very different in their ability to handle situations in which they feel out of control. Our nervous system has two components: the sympathetic system, which makes a patient want to run before getting injected; and the parasympathetic system, which when stimulated, can make an individual faint.
Normally, we're in balance. However, the prospect of having pain, uncertainty about the outcome, as well as many other factors are enough to tip the balance in favor of a vasovagal or syncopal (fainting) fit. The episode is usually self-limited and nonrecurrent. It is not a consequence of the procedure or a warning of some undiagnosed illness. The worst after effect for the patient is embarassment, which is short-lived.

Sometimes patients become very nervous and this can affect their system in such away that they can faint. It is termed a "vasovagal response." As they stand up or sit up they can feel light headed or nauseous and can faint. It is not very common. This can happen under many circumstances, such as from hot weather, or with mild illness that may give the patient low blood pressure or dehydration.