Most patients receiving Botox (botulinum toxin) injections begin to notice effects in 3-5 days, and the maximal effect may take up to 2 weeks to be fully appreciated. Some patients may have a quicker response, just as some patients have extended results (6-8 months over the usual 4-5months)...
I'm not sure if your question of safety of long term iopidine has been addressed. Check with your physician if treatment for your headaches can involve injecting the forehead differently, maybe eliminating lower forehead areas, especially the zones that are located vertically above the eyes....
As we age, the skin gets thin. Botox has no effect at all on skin thickness. Botox softens the lines of facial expression but has no effect on the thickness or on the collagen in your skin.