Is botox mixed with saline or sterile water and once mixed, how long can it be stored for?
Is Botox Mixed with Saline or Sterile Water and Once Mixed, How Long Can It Be Stored For?
Doctor Answers (18)
Botox done by experienced doctors
The storage of a typical bottle of Botox may only be a few days in busy offices. Most doctors use an off-label mixture of saline with preservative to mix their Botox and store it in the refrigerator for up to two weeks if needed, some may hold it longer but that again, is off-label.
Botox is typically reconstituted with normal saline (with or without preservative) and can last for likely up to 6 weeks (some think even longer) when refrigerated. Most busy and successful practices will use up their Botox within 1-3 days.
Mixing and storage of Botox
Botox is mixed with normal saline (bacteriostatic) and can last for several weeks under proper refrigeration. In most practices, it is used up the same day or within a few days.
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Botox is mixed with bacteriostatic saline
Interesting question and am unsure exactly why you are asking, but Botox is mixed with bacteriostatic saline. It is then refrigerated and can be kept there for a few weeks. However, in high volume offices, like mine, I use several vials a day, so the most it sits in there is a few hours.
Studies have shown Botox is stable forup to 6 weeks once reconstituted
Numerous studies have shown that the Botox molecule is stable, even with agitation, for at least 6 weeks after being reconstituted and refrigerated. I have provided a link below of a recent article confirming these observations.
Web reference: http://www.ncbi.nlm.nih.gov/pubmed/21134042
Preparation of Botox
Frankly, I am curious to know why you are asking this question. But to answer you, Botox is reconstituted with sterile saline and can last several weeks in the refrigerator after being mixed. However, in a a busy Botox practice, several vials are used daily so that Botox doesn't sit around mixed for more than a day usually.
Web reference: http://www.barnettdermatology.com/treatments.php?id=37
Mix Botox with Saline
Sterile saline (salt water) is the best liquid for mixing Botox. Although it does last many days reconstituted, many think is slowly loses its potency once mixed.
Many offices like to mix it and use it immediately. We agree with this.
Botox preparation and storage
Botox and other Botulotoxin preparations are normally reconstituted with bacteriostatic normal saline to reduce stinging sensation during injections.
Once reconstituted it should be used up. However, it is believed its efficacy can last from 1-6 weeks if stored in a fridge.
Botox and duration of effectiveness
Botox is reconstituted with sterile saline and can last many weeks in the refrigerator after being mixed. In a busy injector's office, a bottle lasts less than a day.
Botox reconstitution and storage
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.
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