I stored botox in a coolerbox with 5 icepacks at 09:00 in the morning.The following day at 14:00 I realised that I had forgotten to refrigeate it. Can it still be used, or is it now expired?
Will Botox Expire if Left Unchilled for 24 Hours?
Doctor Answers (12)
Botox for Television.
We have used Botox onstage on my partner Drew Ordon's show, The Doctors. We go through great pains to keep it cold but one time it was left out in our office overnight. Unsure if it would work, we tried it out on our staff members. It worked perfectly. We had very happy staff after that!
If you are a physician, I would suggest contacting Allergan directly as they will be able to assist you. Best of luck!
Improperly stored botox
If your botox vials were not reconstituted there might be less of a concern to have been left in the cooler, but if it was diluted already and then left out, it could potentially increase the risk of bacterial growth. If you are a licensed injector, then you should be able to contact Allergan and ask their scientific division your question. They may have privileged information that is not available on line.
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Unchilled Botox may be effective, but be extra cautious.
I agree with the other docs in regards to bacteriostasis. Trial and error will safely tell if it's effective, and keep note of those patients who get this Botox to offer them retreatment if less effective than usual, but I would have a much lower threshold for the time I'd be willing to use a reconstituted vial before tossing. And I agree about using bacteriostatic saline especially in this case.
As long as the Botox was not exposed to heat it should be fine. If you are not satisfied with results after using this Botox, do supplemental injections on those patients.
The rules for botox storage are unclear.
The rules for botox storage are unclear. After reconstitution botox can remain in a refrigerator for a month or more. Our experience is that botox may be left a room temperature for 8 hours and still be effective.
Botox out of the cold
Can Botox left unrefrigerated overnight still be used
It is best to keep Botox refrigerated, but leaving it out of the refrigerator, especially since it was cooled part of the time, for one day should not affect its potency.
BOTOX® is very stable
As a practical matter, we have learned over the past 20 years that BOTOX® is a very stable formulation of BTX-A, and appears to retain full potency for at least several weeks at room temperature after reconstitution using Hospira brand normal saline with 0.9% benzyl alcohol preservative [pH ~5.0].
The fact that BOTOX® [uniquely among the BTX-A formulations commecially available in North America] has a full complement of protective proteins may contribute to its stability, in particular when reconstituted at a low pH.
Having said that, best practice is to keep all BTX-A formulations, including BOTOX®, refrigerated after reconstitution.
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