A biopsy of a lipoma or any other skin lesion involves the injection of a local anesthetic (xylocaine, often with epinephrine to reduce bleeding) around the lesion, and the only discomfort is a few seconds of burning with the anesthetic. There is no pain during or after the procedure.
I Was Ask to Do the Biopsy First Before Deciding to Remove the Lipoma.does Biopsy on a Lipoma Hurt?
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Biopsy of lipoma
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