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Best Sclerotherapy Solution?

I had Sclerotherapy done 3 years ago in FL and the results were wonderful, very noticeable within weeks, continued to get better throughout the 4 procedures I had.

Six weeks ago, I had it done again in Nashville. After 6 weeks, I can't tell any change, actually I only notice the new veins. I don't know which solution was used in FL, but she called it a soapy solution. The clinic here used saline. In your opinion which works best and is better for you to use?

Doctor Answers 14

The size of the varicosity determines the sclero solution.

Sclerotherapy is usually done monthly for 3-6 treatments at a cost of $450 per session.  Usually Asclera is now the most recent solution FDA approved.  Whether by foam or by straight solution, both work very well.

Beverly Hills Dermatologic Surgeon
5.0 out of 5 stars 29 reviews

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Best technique for sclerotherapy of spider veins

Important considerations in sclerotherapy include the proper use of sclerosant solutions, but more importantly, the technique used for injection. Larger veins should be addressed prior to smaller end branches. As a fellow of the American College of Phlebology and a double board certified surgeon who is a Diplomate of the American Board of Phlebology and the American Board of Plastic Surgery, it is important for me to evaluate these venous patterns in a logical and comprehensive fashion prior to having treatment. Do not focus on the sclerosant as much as the surgical planning and knowledge of the treating physician.

Raffy Karamanoukian, MD, FACS
Los Angeles Plastic Surgeon
5.0 out of 5 stars 58 reviews

Sclerotherapy solutions and techniques - Buffalo Niagara, NY

There are many techniques and solutions that are used for sclerotherapy. However, the best at the present time is a foam technique with Asclera. 

Sclerotherapy, sclerotherapy solutions , polidocanol, asclera, Tetra decyl sulfate

There are many types of sclerotherapy solutions and they fall into different categories.  Detergent solutions include sodium tetradecty, Asclera(polidocanol) and sodium morruhate.  These solutions are called detergents because they can be foamed like a soap.  Tetra decyl is stronger than Asclera but Asclera is the sclerosing agent of choice for many of us doing a lot of sclerotherapy.  Sodium morruhate is rarely used because of allergic side effects.  Saline is called an osmotic solution and was once the mainstay of sclerotherapy, but again, this too is now used much less often.  Asclera can be mixed in different concentrations for use in different size veins and can be used as either foam or liquid. Asclera is my sclerosing solution of choice for many reasons-it is painless to inject, it has very few side effects and it can be used as liquid or foam.

John Landi, MD
Naples General Surgeon
5.0 out of 5 stars 4 reviews

What is the best sclerotherapy solution?

I have been injecting leg veins for almost 20 years and there certainly is a difference in solutions.  When I first started out the only option was saline solution injections.  These injections were extremely painful and not as effective as current solutions available.  Asclera is the newest and I believe the best sclerosing solution on the market today.  Yes, the experience of the injector is the most important.  Years ago many doctors touted lasers as the best treatments for spider veins.  Lasers only work on the exquisitely small veins that are too small to be injected.  It is best to be injected several times, approximately one month apart, with Asclera.  If there are tiny tribuaries that remain, these can then be "touched up" with the V-Beam Laser.  It is most important to find an experienced Cosmetic Dermatologist for this and every procedure.

Best Sclerotherapy Solution

It can take up to 8 weeks to appreciate the results from your sclerotherapy treatment. Asclera and Sotradecol are the only 2 FDA approved agents for the treatment of small uncomplicated varicose veins of the legs.  Studies trying to compare the difference between these two agents and hypertonic saline have not shown a significant difference in effectiveness, but hypertonic saline tends to be more painful with injection and has a greater risk for ulcerations.  One must treat the underlying blue veins that feed the superficial spider veins, or treatment of the superficial spider veins will not be proven successful.  Results are dependent on the technique, compression, and sclerosant concentration used for the vein size being treated.

Sabrina Fabi, MD
San Diego Dermatologic Surgeon
5.0 out of 5 stars 42 reviews

What is the best Sclerotherapy Solution

More important than the solution is the injector.  Most of the solutions that physicians use for sclerotherapy work and work fairly well. This is a procedure which is highly operator dependent.  Small vessels such spiders can sometimes be difficult to get into and if you are not experienced it can be troublesome.  Having injected veins for over twenty years I have not seen significant differences in the effectiveness of the solutions but their are some regarding their degree of staining induced  and pain.  Recently the FDA approved a new solution polidocanol, trade name Asclera.  It's main advantage over hypertonic saline is that it is not painful.  Although there are some risks of allergic reaction with polidocano, l it seems to be very small and has become a favorite for many sclerotherapist.

Ted Brezel, MD
Long Island Dermatologist
5.0 out of 5 stars 3 reviews

Patients have Patience!

In my office we offer a variety of solutions depending upon the size of the vessel. We also use a yag laser. Results are generally good, but you must have several treatments and it takes 6-8 weeks for the end results!

David V. Martini, MD
Elkton Facial Plastic Surgeon


we treat our patients with Asclera. We highly recommend it because the consistent results we have. We reccomend 4 to 6 sessions and the cost per session is $450.00

Victoria Karlinsky, MD
Manhattan General Surgeon
4.0 out of 5 stars 15 reviews

Sclerotherapy results may vary by physician!

The most important factor in your sclerotherapy results will be the skill of the physician injector, since the treatment will only work if you get it into the vein!  Keep in mind, that with successive sclerotherapy treatments, the residual veins may be smaller and more resistant.  This makes sense because the larger or more responsive veins have already resolve with your prior sclerotherapy.

Less important the the injector or your vein type, is the solution used.  There are 3 main solutions used-- Hypertonic saline, Sotradecol, and Polidocanol; all of these have excellent track records.  I personally prefer Hypertonic Saline-- there is no chance of an allergic reaction and it responds best with the least side effects in my hands.  Sotradecol (FDA approved in the US) and Polidocanol (not FDA approved) are detergent solutions.  In my experience they burn less, but cause more hyperpigmentation and results are generally not as good as hypertonic saline.

Jeffrey C. Poole, MD
Metairie Dermatologic Surgeon
5.0 out of 5 stars 5 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.