It could be from the original problem

Mary Lupo, MD answers: What should I do to resolve hyaluronidase side effects?

What should I do to resolve the puffiness and swelling in the lower eyelids? Will it resolve over time? If so, how long should I expect to wait? Or has the hyaluronidase done irreversible damage to the tissue of my lower eyelids and the edema is therefore permanent? There is not much information about hyaluronidase on the internet. I look ghastly. Please help.


Mary Lupo, MD
4 months ago

When hyaluronic acid fillers are over-injected, or injected into the incorrect plane, the tissues can swell even after the material is dissolved by hyaluronidase. Allergic reaction is also possible, especially if compounded hyaluronidase was use instead of Vitrase. If you are sleeping on your face or have a high sodium diet, this could increase the problem, so sleep on 2-3 pillows.

I doubt the problem is permanent, but an evaluation by an oculoplastic surgeon would be reasonable to get it checked out.

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