Hi Bixa,
General anesthesia would be painless, but slight overkill.
There are ways to decrease the pain of injections. Lidocaine can be mixed into the Radiesse, lidocaine nerve blocks can be placed, and the skin should be iced before the injections. Topical numbing cream may help a little, but is usually not that effective.
In patients such as yourself, we sometimes recommend that the patient have someone drive them to the office, give them a Xanax and sometimes even add an oral or injected narcotic pain reliever.
For just your nasolabial folds, a nerve block and lidocaine mixed into the Radiesse should be all you need.
Good luck and enjoy.
Dr. P




