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Arnold R. Oppenheim, MD answers: Photodynamic therapy vs. Efudex - which is better for treatment of actinic keratosis?

Photodynamic therapy vs. Efudex - which is better for treatment of actinic keratosis?

I've seen some horrible looking pics posted on the internet from patients that had horrific responses to treatment with FU-5 - they said the pain, oozing (sometimes bleeding) was almost more than they could stand for 2-4 wks. What is a ballpark cost for @ treatment - not sure if my insurance will pay for this but I need to do something about the AK's on my face and forearms - more extensive than than would be practical for cryosurgery - according to my Dermatologist.


Arnold R. Oppenheim, MD
1 month ago

     A recent article by Gold showed that after one year, photodynamic therapy led to a greater clearing of actinic keratoses than Efudex. It should be noted that this finding was applicable if the patient had two photodynamic treatments. Another recent study demonstrated that the use of Aldara (imiquimod) for one month before and a month after photodynamic therapy gave even more outstanding results.

   The treatment can cause a sunburn-like reaction, sometimes even with oozing, but this problem is short-lived. 

    Insurance covers this treatment in most cases. If you do not have insurance, the Kerastick (containing the Levular) costs $135 and the treatment $115.

   Incidentally, the improvement in photoaging is well documented, and though off-label, many physicians offer PDT for this reason. 

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