Chances of Iris Color Change with Latisse?

There is no evidence to suggest that Latisse will change your eye color. The eye is exposed to a very small amount of Latisse even when it is properly applied as directed to the upper eyelid margin using the supplied applicator. This has been demonstrated by applying a colored dye to the eyelid margin and watching its migration. Over two million prescriptions for Latisse have been filled with no confirmed reports of iris pigmentation issues. Side effects from the initial studies showed less... more

The eye color change warning for Latisse involves darkening of light brown or hazel eyes to a darker brown. Latisse does not turn your blue eyes brown. Even to those with light brown eyes, the risk is minimal when Latisse is used correctly, painted on the eyelid and not put directly in the eye. Try it! It is fabulous!

Iris color is unlikely to change with Latisse as long as you use it as directed.  It is only 5% of the dose when  used with the brush on the lid.  In glaucoma the drop is put in the eye.  Even here the change of iris color was about 3%.  Any iris color change is permanent.