Topical Retinoids are clinically effective

Raffy Karamanoukian, MD answers: Is Retin-a the most effective wrinkle cream?

Do anti-wrinkle creams that promise instant smoothing and noticeable reduction in fine lines really work?


Raffy Karamanoukian, MD
9 months ago

The topical retinoids are by far the most clinically effective wrinkles creams available.  They can work long term and results are often immediate after several weeks of use.

The strength of the retinoid plays a major role in the short and long term effectiveness of the retinoid.

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A: Anti-wrinkle creams that promise instant smoothing do work but only last 4-6 hours

David Hansen, MD
11 days ago

Many anti-wrinkle creams are available now and do work but work by irritating the skin to cause edema or swelling to smooth out the lines temporarily and last 4-6 hrs. This is exactly how the lip plumper lipsticks work and last about 2 hours. Retin A or other vit A creams do offer more long term improvement and are always worth using. 

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