Radiesse is generally avoided in the lips due to the bumps and nodules that it can create. Restylane is the best in the lips. Juvederm can also be used in the lips as well. Both of these products have a limited longevity and can last from 6 months to a year. Fat injections are an option in the lips but take a lot of experience and knowledge of lip anatomy and dynamics to create the best result.
Fat transfer, when done well, can last years. But you want to go to a surgeon that has experience doing these in the lips. The length of time fat lasts is tightly related to the technique that is being used. You have to traumatize the fat as little as possible and when you place the fat it has to be layered in small amounts so that the fat can survive and find its own blood supply and environment.
