Liposuction is still the best way to remove fat from anywhere on the body.  There has been improvement in the non-surgical reduction of fat using technology like VelaShape, Thermage, and Reaction.  These Radiofrequency devices can reduce the appearance of cellulite and reduce the circumference of the legs, but are not as effective as liposuction and is not permanent. I will caution you to avoid mesotherapy injections because the "science" has not been fully worked out on this. More research is needed before mesotherapy is accepted by board certified plastic surgeons.