Permanent hypopigmentation is generally caused by irreversible damage to the melanocytes. This can occur as a result of an aggressive immune response or scarring. Inflammation generally causes a stimulation of melanocytes causing hyperpigmentation. Inflammation releases many cell mediators that act to stimulate cell response.
In the case of hypopigmentation after laser treatment, it is conceivable that the laser caused considerable damage to the melanocytes, but this is highly unlikely. A more likely scenario is that the resulting inflammation and post-inflammatory pigmentation caused by the Fraxel actually unearthed damaged skin or even scar that was not apparent to you prior to treatment.
The goal would be to reestablish an even skin tone. The best thing to do at this point would be to conservatively manage the skin without topical or laser treatments and consult with an experienced physican who is an expert in the physiology and cosmetic treatment of skin pigmentation.


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