Accutane or isotrentinoin is a profound drug. It is very effective for the long term control of severe nodulocystic acne. Accutane affects the oil glands and stem cells of the skin and inhibits angiogenesis, the formation of new blood vessels. Some of these changes appear to be permanent.
It is widely believe that Accutane has a long term effect on skin healing. While studies on this subject are limited, medical reports have established an association between current or recent Accutane use and unpredictable scaring after dermabrasion, laser treatment, and surgery, including rhinoplasty. Animal studies on the affects of recent Accutane treatment and wound healing are less clear. These studies fail to show that isotrentinoin affects collagen synthesis.
Generally, it is accepted that current or recent isotrentinoin treatment affects wound healing and increases the risk of delayed healing and keloid formation. For these reason, it is generally recommended that one wait 12 to 24 months before having a full face chemical peel, laser resurfacing, or elective surgery. In contrast, some clinicians feel that surgery is safe once the facial skin is producing oils. Given the potential risks it is prudent to err on the side of abundant caution in these circumstances.
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