Disodium Cocoamphodiacetate

The safety of these ingredients has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. The CIR Expert Panel evaluated the scientific data and concluded that Sodium Cocoamphoacetate, Sodium Cocoamphopropionate, Disodium Cocoamphodiacetate, and Disodium Cocoamphodipropionate were safe as cosmetic ingredients in the present practices of use. In 2006, as part of the scheduled re-evaluation of ingredients, the CIR Expert Panel considered available new data on these four ingredients, and reaffirmed the above conclusion.CIR Safety Review: Sodium Cocoamphoacetate, Disodium Cocoamphodiacetate, Sodium Cocoamphopropionate and Disodium Cocoamphodipropionate were nontoxic in acute oral toxicity studies. The results of ocular irritation studies of these compounds varied depending on the test conditions. In a clinical ocular study, 1%, 3% and 10% dilutions of a shampoo containing 28.1% Disodium Cocoamphodiacetate were nonirritating to the human eye. Sodium Cocoamphopropionate, Disodium Cocoamphodiacetate, and Disodium Cocoamphodipropionate were nonmutagenic in a bacterial assay, both with and without metabolic activation. Sodium Cocoamphoacetate and Sodium Cocoamphopropionate, at a concentration of 10%, were neither irritants nor sensitizers in a repeated insult patch test. The CIREP concluded that these ingredients were safe for use in personal care products.

Sodium Cocoamphoacetate, Sodium Cocoamphopropionate, Disodium Cocoamphodiacetate and Disodium Cocoamphodipropionate may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Directive of the European Union.
Link to the EU Cosmetics Directive: http://ec.europa.eu/enterprise/cosmetics/html/consolidated_d...