Diisopropyl Dimer Dilinoleate

The safety of these six ingredients has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. The CIR Expert Panel evaluated the scientific data and concluded that Diisopropyl Dimer Dilinoleate, Dicetyl Dimer Dilinoleate, Diisostearyl Dimer Dilinoleate, Dioctyl Dimer Dilinoleate, Dioctyldodecyl Dimer Dilinoleate and Ditridecyl Dimer Dilinoleate were safe as used in cosmetics and personal care products.CIR Safety Review: Safety test data on dilinoleic acid were considered relevant because dilinoleic acid is a component of these diesters and a likely breakdown product. These ingredients did not produce skin or ocular irritation, nor were they comedogenic. Mutagenicity tests in bacteria, clastogenicity studies in human lymphocytes in culture, and L5178Y lymphoma cell forward mutation studies were all negative, indicating no dilinoleic acid genotoxicity. No carcinogenicity studes were available; however, structural alerts that suggesting a mutagenic or carcinogenic risk were absent.

Significant reproductive/developmental toxicity or other systemic toxicity were not expected with these ingredients because they were poorly absorbed from the skin and were found to remain on the skin's surface. In clinical studies, cosmetic formulations containing these ingredients did not produce skin irritation or sensitization, although one report of sensitization to dilinoleic acid appeared in the case literature. The CIR Expert Panel did note that the concentration of use of Diisopropyl Dimer Dilinoleate was reportedly as high as 53% in lipsticks, but that the highest concentration tested for irritation/sensitization was 27%. Given the size of these molecules, their relative insolubility in water, their lipophilic nature, and the absence of any significant case reports of allergic reactions, a use concentration of 53% is not likely to be associated with any adverse effects.

Diisopropyl, Dicetearyl, Diisostearyl, Diethylhexyl, Dioctyldodecyl and Ditridecyl Dimer Dilinoleate may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Directive of the European Union.
Link to the EU Cosmetics Directive: http://ec.europa.eu/enterprise/cosmetics/html/consolidated_d...