Hyaluronidase
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Did Hyaluronidase cause allergic reaction?

By LALA LADY on 17 Sep 2008

I had an injection of Hyaluronidase (i think). It was an injection to dissolve some restylane that I was not happy with. I now have what looks like a blister where the Hyaluronidase was injected. The blister has gotten larger over the course of several hours. Is this an allergic reaction? When will it go away?

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kakie (8 posts) 20 Jun 2009
I also had a reaction from hyaluronidase injection to dissolve restylane from under my eyes.Initially after the injection my eyes looked good. However,about 4 hours later they started swelling a lot and turned red. It's now day 4 of taking a taking MethylPrednisolone tablets. Any guess as to how long it will take for the swelling and my eyes to look normal again?
ANAN (11 posts) 21 Jun 2009
Someone please answer her because I'm having a similar problem with my over swelling from the hyaluronidase injections under my eyes and it's been 5 days and no improvement whatsoever. What do I do? Please help. Thank you.
kakie (8 posts) 22 Jun 2009
This is an update to my original post. It is now day 6 of taking the MethylPrednisolone tablets and it is helping the swelling, but not as quickly as I had hoped and the tablets make me feel a bit wierd (weak feeling,etc.). Does the allergic reaction from the hyaluronidase take long to get out of the system or is it just swelling that takes a long time to go away or is it both? Any info regarding hyaluronidase help as there is little on the internet out it.
eyebaghell (13 posts) 23 Jun 2009
I would be VERY interested to know how common these reactions are as I have had restylane injected for my tear troughs and not very happy with the result. My surgeon disagrees and thinks it looks great but I want it disolved with hyaluronidase. As I am getting married in 5 weeks times however I am reluctant to start messing about with my eyes as its obviously a delicate area and judging by some of these posts I might make things worse!? ANY HELPFUL INFORMATION APPRECIATED! I'm in the UK x
kakie (8 posts) 23 Jun 2009
To eyebaghell - I would recommend checking into having an expericed doc remove the restylane by making a very fine incesion (nothing that leaves a mark)to take out the restylane. I wished I would have done that instead of the hyaluronidase. You have 5 weeks before the wedding, so if you check into it right away, you might save yourself a lot of stress. I will never do fillers again.
eyebaghell (13 posts) 25 Jun 2009
To Kakie. Thanks for the advice but I cant get any surgeon to do the extraction - because the restylane has been injected so deep (under the muscle) the only way to get it out apparantly is to have it dissolved with hyaluronidase. I am going next week to have the hyaluronidase injections - exactly 4 weeks before my wedding. I am scared out my head but really want it out. If you could update me on how your allergy is going - that would be much appreciated. I really hope things have settled for you now and pray I dont have a reaction. I too will never have fillers again - why oh why couldnt I just be content with the hand I was dealt - hopefully this will teach me a lesson :-( x
kakie (8 posts) 25 Jun 2009
Eyebaghell, the hyaluronidase will probably work fine for you. Most people don't have reactions and I'm back to looking almost like I did before the hyaluronidase. If I wasn't allergic to it, I would have to have more injected as it appears that some is still left and I still look lumpy. It's been 10 days since I had the hyaluronidase injected, so your timing should work. Please let me know how it turns out for you. I go back in for a follow-up tomorrow, but doubt that I'll be doing anything except keeping my sunglassses on for the next 4 months. It's been a hard and stressful lesson.
kakie (8 posts) 25 Jun 2009
Eyebagshell, I don't know if I told you this, but the reason I got the filler was because my daughter was getting married and I wanted to look my best and that was 3 weeks before her wedding! The doctor told me that I would look fabulous withing a couple of days! Needless to say, I didn't look my best, but thankfully I had a makeup artist that was skilled and she was able to hide a lot of it.
ANAN (11 posts) 27 Jun 2009
kakie, how many days has it been since your allergic reaction and since you've been taking meds to alleviate the swelling? did the meds work? did they take away the blister look you were describing? i'm having the same problem with my hyaluronidase injection but haven't taken any meds for it. hope yours is better.
kakie (8 posts) 28 Jun 2009
It has been 13 days since the allergic reaction and 5 days since I completed taking the meds. The blister look has improved a lot, but I still have some swellin in one eye and some discoloration. I can hide most of it with concealer. I probably could use another injection of hyaluronidase to dissolve all of the restylane, but I'm not going to since I had a reaction. I can't wait for it all to return to normal.
ANAN (11 posts) 29 Jun 2009
i'm afraid to have more hyal injections too. hoping time will heal us both. we'll have to stay positive.
eyebaghell (13 posts) 5 Jul 2009
Hi all. Just to update you on my experience. I had the hyaluronidase injected on Friday. Was very nervous but my surgeon assured me it would be ok - he is an ocuplastic surgeon and uses hyaluronidase regularly in surgery. The injections were completely painless and very quick. Afterwards I did swell - 2 blister type swells under each eye so was worried after hearing your experiences. However within a couple of hours swelling was gone and restylane already started to dissapear - by 5/6 hours later restylane was almost completely gone and by next morning 100% back to normal. I am so relieved and over the moon to be looking like 'me' again. My tear troughs are still noticeable and I cant say they dont bother me but the restylane just looked too artifical and you could see it under my skin - not asthetically what I had imagined. So now I can actually look forward to getting married without worrying about what a terrible mistake I had made :-) I hope everything with you both has settled now and that things are on track to getting back to normal. This website has helped me to express my concerns and ask questions but I do think it is important for people reading this to remember that every case is individual and that the most important thing is to seek out a qualified and reputable surgeon/dermatologist that you can trust. I also think that fillers like restylane seem like a 'safe' option which is why people are who wouldnt normally consider cosmetic treatments are taking the plunge. But as you will see on this website this isnt always the case - so dont jump into having injections without thinking long and hard about what you might be getting yourself into!
eyebaghell (13 posts) 5 Jul 2009
Hi all. Just to update you on my experience. I had the hyaluronidase injected on Friday. Was very nervous but my surgeon assured me it would be ok - he is an ocuplastic surgeon and uses hyaluronidase regularly in surgery. The injections were completely painless and very quick. Afterwards I did swell - 2 blister type swells under each eye so was worried after hearing your experiences. However within a couple of hours swelling was gone and restylane already started to dissapear - by 5/6 hours later restylane was almost completely gone and by next morning 100% back to normal. I am so relieved and over the moon to be looking like 'me' again. My tear troughs are still noticeable and I cant say they dont bother me but the restylane just looked too artifical and you could see it under my skin - not asthetically what I had imagined. So now I can actually look forward to getting married without worrying about what a terrible mistake I had made :-) I hope everything with you both has settled now and that things are on track to getting back to normal. This website has helped me to express my concerns and ask questions but I do think it is important for people reading this to remember that every case is individual and that the most important thing is to seek out a qualified and reputable surgeon/dermatologist that you can trust. I also think that fillers like restylane seem like a 'safe' option which is why people are who wouldnt normally consider cosmetic treatments are taking the plunge. But as you will see on this website this isnt always the case - so dont jump into having injections without thinking long and hard about what you might be getting yourself into!
ANAN (11 posts) 5 Jul 2009
eyebaghell, THAT'S GREAT! i'm so happy for your success with hyal injections and i'm even more thrilled for you that you can have your wedding and feel good about what you see and your groom sees. you were definitely one of the lucky ones with the hyal, since you said you were 100% back to normal within a day. i have not had that experience so i guess my body just adjusts to hyal much differently. so, i'm not out of hot water yet but i remain positive that i will be back to normal with some more time. hoping not too much more. but congratulations again! i am stoked for you!!!!!!
pretty eyes no more (1 post) 27 Jul 2009
I had Juvederm injected by an unskilled doctor (didn't realize at the time) and he put it right under my eyes and I looked like I had been in a bad fight or car accident under my eyes. I had asked him to put the Juvederm in my cheeks---he injected at my cheeks but aimed the needle straight up towards my undereye every time, where the hyaluronic Juvederm landed. He put the Amphase under my eyes the next week and it took it down some. There was so much that the poofiness had not gone away completely like I wanted so a few weeks later I went back for more. He put so much in one eye that my eye swelled shut, from what I assume to be a really bad allergic reaction. Now, six months later, only in that eye I have developed a large bag under my eye from the tissues being broken down from the Amphadase. Since he put too much, my naturally bag-free pretty eyes have made me look very old and tired with grey-blue puffiness. I have looked online everywhere to see how long Amphase lives in the body and how to deactivate it, but I can't find it anywhere. Please don't use hyalurondase unless you absolutely have to. I wish I would have just waited it out, or else used the MINIMAL amount. I looked so much better before.
Usha Rajagopal, MD (127 posts) 1 Aug 2009

One of the most common side effects to Hyaluronidase injections is an allergic reaction. In general, Hyaluronidase purchased from a manufacturer is less prone to causing an allergic reaction than Hyaluronidase purchased at a compounding pharmacy (when the pharmacist prepares the compound at the pharmacy). If it is an allergic reaction, you could resolve the issue by taking Benedryl or a a steroid.

View answers from Usha Rajagopal, MD
Veteran (1 post) 28 Sep 2009
I had restylane injected into the naso-labial lines, but the needle was aimed upwards and it went into the lower part of my cheek on the right hand side, making my face feel tight when I smiled. I went back to have hyaluronidase injected into the lower right cheek and immediately got a swelling, which felt like an allergic reaction. My 'mistake' was to place ice on the swollen area, as this moved the swelling up into my eye socket, the next day when I woke up my eye and face were swollen, but I put a cool fan in the direction of my face for a few hours and over the course of the day, the swelling reduced. A day later my face was back to normal and the restylane in the lower part of my right cheek had been reduced. I think the eye area, where some people have restylane injected, make take a little longer to return to normal, after the hyaluronidase allergic reaction. I only wish the possible effects of the hyaluronidase had been explained to me from the outset, which would have saved a lot of panic.
BigSis (1 post) 6 Feb 2010
My brother was injected in his back with hyaluronidase after failed back surgery. He had a reaction and developed blister at injection site, arachnoidities, a stroke, permanent paralysis (t2 down to his feet) and then death.
Chris Thiagarajah, MD (284 posts) 21 Aug 2010
There is case report of hyaluronidase causing an allergic reaction in a patient. It is a rare complications (1 patient reported in the literature) and it is used for noncosmetic purposes every single day. It is derived from porcine or bovine sources so it is a possibility. The patient should have had pre exposure though. (Like a bee sting, if you are allergic it shouldn't do anything the first time you get it, but the second time) You need to be sensitized first. In the case report, the patient got back to normal over a couple of weeks.
View answers from Chris Thiagarajah, MD
moonface (2 posts) 28 Sep 2010
Hi had restylane 4 months ago with no obvious problems. Ten days ago noticed a few lumpy swellings developing on the sides oft mouth chin and tear marks. Since then it has been getting worse with each day bringing new lumps that are not always where the original injections occurred. I look like a chipmunk in the morning and my face is losing it's definition. Help anyone got any advice? I am beginning to get really scared. Had 5 days on steroids but no luck. Any advice would be great.
Mandy0000 (9 posts) 20 Apr 2011
Never use hyaluronidase!!! unless its by a profession but then again l got it done by a a profession to and my eyes are never the same again, it left it hollowed and dented....devastated
Ro ro (1 post) 6 Aug 2011
Dear Moonface, I am reliving your exact scenario. I have lumps and bumps that I developed almost 9 weeks after my restalyne injections. They move daily and are sore. I am afraid to get any more injections of anything and I just don't know what to do? I am so miserable and so sorry I took the plunge as I researched and believe this was safe. Please tell me how you made out as your situation was last year . Anyone with any suggestions I am eagerly awaiting. Hoping to hear you are better moonface. I fear that I may be allergic to the hyla. Injections since the restalyne has reacted the way it has on me? Thanks .
moonface (2 posts) 8 Aug 2011
You poor thing! I found a fab cosmetic surgeon who with steroid injections, oral steroids and hyulondaise jabs over a course of some weeks sorted me out!! Don't leave it ... The sooner you get help the better. I am 10 mo tbs on and so far am great.. Really there is help but you need to get it ASAP as the longer it is left the harder it is to correct. Good luck. Let me know how you get on.

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