Did Hyaluronidase cause allergic reaction?

Ro ro 24 Oct 2012

Learned the hard way. I feel I was NOT fully informed by thie " well" respected Doctor I went to. Afer 10 weeks of abtiobiotic's, a huge moon face, steriods and such fear and anxiety over the out come, I can say none of this was worh it. Once you start to dig, you will see just how many people suffer adverse side effects. No ONE talks to you about this prior to these injections. It is horrifying! I woke up 7 weeks after my injections swollen, and had lumps the size of my thumb all over my face. They hurt and every day they would travel. I was DISTRAUGHT. My friend 's nasal paasages collapsed for a year and a half. It was a hard lesson to learn. I hate wrinkles but will and have learned to accept them graciously rather then ever living through this night mare again. It took a long time, but eventually the lumps disappated. I hope and pray there will be no long term effects. I was supposedly injested with restylane and dysport??????? So all of you in the midst of this find a great conservative Doctor to get you throuigh this. It will pass eventually. You have my prayes and support for sure. xo

moonface 8 Aug 2011

You poor thing! I found a fab cosmetic surgeon who with steroid injections, oral steroids and hyulondaise jabs over a course of some weeks sorted me out!! Don't leave it ... The sooner you get help the better. I am 10 mo tbs on and so far am great.. Really there is help but you need to get it ASAP as the longer it is left the harder it is to correct. Good luck. Let me know how you get on.

Ro ro 6 Aug 2011

Dear Moonface, I am reliving your exact scenario. I have lumps and bumps that I developed almost 9 weeks after my restalyne injections. They move daily and are sore. I am afraid to get any more injections of anything and I just don't know what to do? I am so miserable and so sorry I took the plunge as I researched and believe this was safe. Please tell me how you made out as your situation was last year . Anyone with any suggestions I am eagerly awaiting. Hoping to hear you are better moonface. I fear that I may be allergic to the hyla. Injections since the restalyne has reacted the way it has on me? Thanks .

Mandy0000 20 Apr 2011

Never use hyaluronidase!!! unless its by a profession but then again l got it done by a a profession to and my eyes are never the same again, it left it hollowed and dented....devastated

moonface 28 Sep 2010

Hi had restylane 4 months ago with no obvious problems. Ten days ago noticed a few lumpy swellings developing on the sides oft mouth chin and tear marks. Since then it has been getting worse with each day bringing new lumps that are not always where the original injections occurred. I look like a chipmunk in the morning and my face is losing it's definition. Help anyone got any advice? I am beginning to get really scared. Had 5 days on steroids but no luck. Any advice would be great.

Chris Thiagarajah, MD 21 Aug 2010

There is case report of hyaluronidase causing an allergic reaction in a patient. It is a rare complications (1 patient reported in the literature) and it is used for noncosmetic purposes every single day. It is derived from porcine or bovine sources so it is a possibility. The patient should have had pre exposure though. (Like a bee sting, if you are allergic it shouldn't do anything the first time you get it, but the second time) You need to be sensitized first. In the case report, the patient got back to normal over a couple of weeks.

View answers from Chris Thiagarajah, MD

BigSis 6 Feb 2010

My brother was injected in his back with hyaluronidase after failed back surgery. He had a reaction and developed blister at injection site, arachnoidities, a stroke, permanent paralysis (t2 down to his feet) and then death.

Juliabars 16 Oct 2012

My goodness. I'm so sorry to hear that. Did any doctors explain how the hyaluronidase might have caused such a fatal reaction?

BigSis 17 Oct 2012

Thank you so much. The doctors (about 5 of them) would not entertain the idea that the hyaluronidase could have caused his illness. They were so afraid of getting involved in a lawsuit that all they would do to help was to treat the many illnesses and symptoms. There were so many reason why my brother should not have been injected with hyaluronidase by the pain doctor. And what about the recent scare across the country about the steroid causing meningitis? My brother also developed meningitis in the beginning. The whole ordeal was and is still a nightmare. October 29th will be 6 years since his death. I could write a book about what all happened. Thanks again for you kind remark.

Juliabars 17 Oct 2012

You're welcome. Please do write a book. I fully support that. There really needs to be more advocacy in awareness of cosmetic and plastic surgery dangers in a more public and widely distributed way. A life isn't something to be taken for granted, but unfortunately it seems as though many plastic surgeons think the opposite.

BigSis 24 Oct 2012

The doctor that injected the hyaluronidase into my brother injected it into his spine in conjunction with a steriod injection. During my research I discovered that hyaluronidase is used during eye surgery and cosmetic as well. But this doctor decided to use the compounded material to get through scar tissue in order to make the steroid more effective. Either the material was contaminated or it was a bad procedure by the doctor. Did you know that at one time hyaluronidase was manufactured from sheep testicular tissue? Have you heard the news as of late about the folks dying and getting sick from the fungal infected steriods being injected into peoples spines? Well, this gives me even more reason to get my brother's story out there. In 5 days it will be 6 years since my brother's death. I was his health care advocate and caretaker for almost a year....for some reason I feel like my role in being an advocate for this cause is not over..... What is your story?

Veteran 28 Sep 2009

I had restylane injected into the naso-labial lines, but the needle was aimed upwards and it went into the lower part of my cheek on the right hand side, making my face feel tight when I smiled. I went back to have hyaluronidase injected into the lower right cheek and immediately got a swelling, which felt like an allergic reaction. My 'mistake' was to place ice on the swollen area, as this moved the swelling up into my eye socket, the next day when I woke up my eye and face were swollen, but I put a cool fan in the direction of my face for a few hours and over the course of the day, the swelling reduced. A day later my face was back to normal and the restylane in the lower part of my right cheek had been reduced. I think the eye area, where some people have restylane injected, make take a little longer to return to normal, after the hyaluronidase allergic reaction. I only wish the possible effects of the hyaluronidase had been explained to me from the outset, which would have saved a lot of panic.

Usha Rajagopal, MD 1 Aug 2009

One of the most common side effects to Hyaluronidase injections is an allergic reaction. In general, Hyaluronidase purchased from a manufacturer is less prone to causing an allergic reaction than Hyaluronidase purchased at a compounding pharmacy (when the pharmacist prepares the compound at the pharmacy). If it is an allergic reaction, you could resolve the issue by taking Benedryl or a a steroid.

View answers from Usha Rajagopal, MD

pretty eyes no more 27 Jul 2009

I had Juvederm injected by an unskilled doctor (didn't realize at the time) and he put it right under my eyes and I looked like I had been in a bad fight or car accident under my eyes. I had asked him to put the Juvederm in my cheeks---he injected at my cheeks but aimed the needle straight up towards my undereye every time, where the hyaluronic Juvederm landed. He put the Amphase under my eyes the next week and it took it down some. There was so much that the poofiness had not gone away completely like I wanted so a few weeks later I went back for more. He put so much in one eye that my eye swelled shut, from what I assume to be a really bad allergic reaction. Now, six months later, only in that eye I have developed a large bag under my eye from the tissues being broken down from the Amphadase. Since he put too much, my naturally bag-free pretty eyes have made me look very old and tired with grey-blue puffiness. I have looked online everywhere to see how long Amphase lives in the body and how to deactivate it, but I can't find it anywhere. Please don't use hyalurondase unless you absolutely have to. I wish I would have just waited it out, or else used the MINIMAL amount. I looked so much better before.

eyebaghell 5 Jul 2009

Hi all. Just to update you on my experience. I had the hyaluronidase injected on Friday. Was very nervous but my surgeon assured me it would be ok - he is an ocuplastic surgeon and uses hyaluronidase regularly in surgery. The injections were completely painless and very quick. Afterwards I did swell - 2 blister type swells under each eye so was worried after hearing your experiences. However within a couple of hours swelling was gone and restylane already started to dissapear - by 5/6 hours later restylane was almost completely gone and by next morning 100% back to normal. I am so relieved and over the moon to be looking like 'me' again. My tear troughs are still noticeable and I cant say they dont bother me but the restylane just looked too artifical and you could see it under my skin - not asthetically what I had imagined. So now I can actually look forward to getting married without worrying about what a terrible mistake I had made :-) I hope everything with you both has settled now and that things are on track to getting back to normal. This website has helped me to express my concerns and ask questions but I do think it is important for people reading this to remember that every case is individual and that the most important thing is to seek out a qualified and reputable surgeon/dermatologist that you can trust. I also think that fillers like restylane seem like a 'safe' option which is why people are who wouldnt normally consider cosmetic treatments are taking the plunge. But as you will see on this website this isnt always the case - so dont jump into having injections without thinking long and hard about what you might be getting yourself into!

ANAN 5 Jul 2009

eyebaghell, THAT'S GREAT! i'm so happy for your success with hyal injections and i'm even more thrilled for you that you can have your wedding and feel good about what you see and your groom sees. you were definitely one of the lucky ones with the hyal, since you said you were 100% back to normal within a day. i have not had that experience so i guess my body just adjusts to hyal much differently. so, i'm not out of hot water yet but i remain positive that i will be back to normal with some more time. hoping not too much more. but congratulations again! i am stoked for you!!!!!!

ANAN 29 Jun 2009

i'm afraid to have more hyal injections too. hoping time will heal us both. we'll have to stay positive.

eyebaghell 5 Jul 2009

Hi all. Just to update you on my experience. I had the hyaluronidase injected on Friday. Was very nervous but my surgeon assured me it would be ok - he is an ocuplastic surgeon and uses hyaluronidase regularly in surgery. The injections were completely painless and very quick. Afterwards I did swell - 2 blister type swells under each eye so was worried after hearing your experiences. However within a couple of hours swelling was gone and restylane already started to dissapear - by 5/6 hours later restylane was almost completely gone and by next morning 100% back to normal. I am so relieved and over the moon to be looking like 'me' again. My tear troughs are still noticeable and I cant say they dont bother me but the restylane just looked too artifical and you could see it under my skin - not asthetically what I had imagined. So now I can actually look forward to getting married without worrying about what a terrible mistake I had made :-) I hope everything with you both has settled now and that things are on track to getting back to normal. This website has helped me to express my concerns and ask questions but I do think it is important for people reading this to remember that every case is individual and that the most important thing is to seek out a qualified and reputable surgeon/dermatologist that you can trust. I also think that fillers like restylane seem like a 'safe' option which is why people are who wouldnt normally consider cosmetic treatments are taking the plunge. But as you will see on this website this isnt always the case - so dont jump into having injections without thinking long and hard about what you might be getting yourself into!

kakie 28 Jun 2009

It has been 13 days since the allergic reaction and 5 days since I completed taking the meds. The blister look has improved a lot, but I still have some swellin in one eye and some discoloration. I can hide most of it with concealer. I probably could use another injection of hyaluronidase to dissolve all of the restylane, but I'm not going to since I had a reaction. I can't wait for it all to return to normal.

kakie 25 Jun 2009

Eyebagshell, I don't know if I told you this, but the reason I got the filler was because my daughter was getting married and I wanted to look my best and that was 3 weeks before her wedding! The doctor told me that I would look fabulous withing a couple of days! Needless to say, I didn't look my best, but thankfully I had a makeup artist that was skilled and she was able to hide a lot of it.

ANAN 27 Jun 2009

kakie, how many days has it been since your allergic reaction and since you've been taking meds to alleviate the swelling? did the meds work? did they take away the blister look you were describing? i'm having the same problem with my hyaluronidase injection but haven't taken any meds for it. hope yours is better.

Pinkwillow 12 Mar 2012

The same thing is happening to me too!! I also have a deep groove under my eye that is getting worse with time along with the bag under my right eye. I looked way better before all these darn injections of restylane and then hydro. to dissolve a bit. I am 10 days after hydro and looking like I stepped out of movie "night of the living dead"! This is ruining my life and no on has answers for me. I also have a kid to raise and all I wanna do is hide. Thats all I have been doing.

mom21 20 Mar 2012

This has happened to me too! Exactly! There has been zero improvement since hylauranadase 4 mos. ago. Deep crease in right tear trough looks worse w/ darkness and puffiness. Docs are no help! Teamine cream does help a little.

Pinkwillow 16 Oct 2012

I have now had 4 rounds of hyalarondaise and I still look sooo bad. It actually looks like a a cyst under my eye about the size of a small kidney bean. It is now Oct. and all of year since it started in late Feb. I have been hiding behind sunglasses. I dont even look in the mirror anymore because I dont recognize myself. I am unemployed and a single mom and now facing having my son taken away because of severe anxietey to leave my house and do simple grocery shopping. Every mirror I face I have a pannick attack. Just a matter of days before social workers come knocking.

kakie 25 Jun 2009

Eyebaghell, the hyaluronidase will probably work fine for you. Most people don't have reactions and I'm back to looking almost like I did before the hyaluronidase. If I wasn't allergic to it, I would have to have more injected as it appears that some is still left and I still look lumpy. It's been 10 days since I had the hyaluronidase injected, so your timing should work. Please let me know how it turns out for you. I go back in for a follow-up tomorrow, but doubt that I'll be doing anything except keeping my sunglassses on for the next 4 months. It's been a hard and stressful lesson.