Rod J. Rohrich, MD

All current FDA approved fillers as safe if used and injected properly.  The key to good results in the use of fillers is to find a Plastic Surgeon who does his own filler injections and who is knowledgeable about which filler works the best for which area. 
For instance, I use Juvederm preferentially over Restylane for the lips as it is smoother and softer . On the other hand, I prefer Restylane for correction of the tear trough area around the eyes as it can last well over one year.

I like Radiesse which is a longer lasting filler for the nasolabial folds and reshape the patients cheeks  and for deeper nasolabial folds.

I often use Botox in conjunction with a filler as it allows the filler to last about 50% longer to reshape the both the upper and lower face.