Evolence Guide

What it is: Evolence is a collagen-based injectable cosmetic filler used to restore facial volume and treat moderate to deep facial wrinkles and folds.

Inside this Guide Content provided by the American Society for Aesthetic Plastic Surgery, ASAPS
1. Types of Dermal Fillers 6. Evolence Results: what to expect
2. Is Evolence Safe? 7. Evolence Side Effects
3. Who should consider Evolence? 8. Evolence Cost
4. Doctor Consultation: what to ask 9. Terminology to know
5. What happens during an injection?  

Search terms:  Cosmetic Fillers, Cosmetic Injectables, Evolence Injection, Collagen Injection

Types of Dermal Fillers

Cosmetic or dermal fillers are generally classified in two main categories:

Temporary dermal fillers include two categories: collagen and hyaluronic acid fillers. Collagen is a naturally occurring connective tissue component that provides strength and structure to the skin. Hyaluronic acid is a naturally occurring substance between the skin cells that binds moisture and provides fullness. Both collagen and hyaluronic acid injectable dermal fillers are created in a lab to mimic these natural substances.

Semi-permanent and permanent dermal fillers are those used to correct deeper facial creases and in larger volume restoration. These fillers generally include microsphere particles suspended into a liquid or gel formulation or compounds that do not readily absorb, injected deep within the soft tissue for more long-lasting and large volume correction.Evolence was approved by the FDA in June 2008

Evolence is a temporary collagen-based cosmetic filler lasting 6 months or more.

Is Evolence Safe?

Evolence was approved in June, 2008 by the US FDA to correct moderate to deep facial wrinkles and folds.

When prescribed by a properly qualified and trained doctor and injected in an appropriate medical setting, U.S. FDA-approved dermal fillers are extremely safe.

Who Should Consider Evolence?

The following conditions can be treated with cosmetic fillers such as Evolence:

  • fine lines, wrinkles
  • moderate to deep facial folds

Doctor Consultation: what to ask

The first step in considering Evolence is to meet with your doctor or properly qualified and trained clinician.

What happens during an Evolence injection?

  • The area to be injected will be cleansed, commonly with alcohol swabs. A topical anesthetic cream, icing to the injection sites or a local anesthetic via injection (such as a dental block) may be used for your comfort.
  • Once your treatment region in numbed, your doctor will make injections in several locations, placing the dermal filler where correction or volume enhancement is desired.
  • You doctor may massage or manipulate the area where the filler has been placed. The treated area may be cleansed again.
  • You may be given ice or cold packs to place on the treated area to minimize swelling and bruising.
  • The entire treatment process may take 20 to 30 minutes or more.

Evolence Results: what to expect

Your enhancement will be visible immediately after your injections. However, due to swelling, you may look a little fuller than you might expect. This will improve rapidly over the next few days.

  • You may experience mild swelling or bruising from any type of injection. Ice or cold packs can help to minimize swelling or discomfort.
  • You can generally apply makeup over the treated area immediately.
  • Collagen fillers may result in 2-3 days of swelling and are less likely to result in bruising or redness.

The improvement from Evolence begins to diminish within 6 to 12 months after treatment.

If you do not repeat treatment once your results have begun to diminish, or as directed by your doctor, your appearance will return to its pre-treatment state.

Evolence Side Effects

Cosmetic injection risks include:

  • hematoma or blood pooling beneath the skin
  • infection and necrosis or skin loss is possible (although rare)
  • an unsatisfactory outcome

Evolence may be visible or felt if injected superficially. In very rare cases may develop nodules (small bumps beneath the skin).

The greatest risk occurs when dermal fillers are injected by someone who is not properly qualified to perform injections. Semi-permanent and permanent fillers may carry a risk of clumping (the particles form a granuloma or lump that can be felt or seen beneath the skin). Particles may also migrate or displace from the injection site. Injection of an anti-inflammatory may help to improve minor clumps or swelling. More significant conditions of clumping or granuloma may require surgery.

Evolence Cost

Evolence injections can vary widely in cost as reflected in the Evolence cost data posted on RealSelf.com. The cost of Evolence may vary based on your provider's experience, the number of injection sites, as well as geographic office location.

Evolence Terminology to know

  • Collagen: Connective tissue component of skin. U.S. FDA approved collagen dermal fillers include Cosmoderm and Cosmoplast (synthetically derived), Zyderm and Zyplast (bovine collagen) and Evolence (porcine collagen).  
  • Dermal filler: An injected or implanted medical device that plumps or shapes the skin.
  • Injector: Commonly used term to identify and individual who provides cosmetic.
  • Johnson & Johnson:  Johnson & Johnson is a manufacturer of health care products, as well as a provider of related services, for the consumer, pharmaceutical and medical devices and diagnostics markets. The aesthetics group of Johnson & Johnson OrthoNeutrogena includes the dermal filler Evolence.
  • Granuloma: A small bump that can be seen or felt beneath the skin that can result from particle-based dermal fillers.
  • Numbing cream: A form of anesthetic by topical cream to numb tissue prior to injections or laser procedures.
  • Nurse Injector: A common term for a registered nurse who provides cosmetic injectables treatments. Some states restrict or do not allow the practice of nurse injectors.
  • Off-label: The practice of prescribing drugs or medical treatment for a purpose similar too, but specifically not defined by a drug's U.S. FDA approved label.
  • Porcine Collagen: Derived from porcine (pig) tendons, a highly purified collagen used in the manufacture of Evolence.
  • Topical anesthetic: A local anesthetic agent applied to numb the surface of an tissue, such as skin or gums.

Source: American Society for Aesthetic Plastic Surgery 

Last updated: 11/2008

Last modified 12 months ago